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The Ocular Hypertension Treatment Study and Its Impact
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The Ocular Hypertension Treatment Study and Its
Impact
BY AMY SUITER, CATHY SARLI, KAREN GUTZMAN AND MICHELLE DOERING
August 18, 2014
The Ocular Hypertension Treatment Study (OHTS), 1992-2012, was a randomized controlled multi-center
clinical trial conducted in 22 clinical centers in the United States funded by the National Eye Institute of the
National Institutes of Health (EY09307). OHTS was designed to determine whether lowering intraocular
pressure (IOP) in individuals with ocular hypertension delays or prevents the development of primary open
angle glaucoma (POAG) and risk factors for the development of POAG. The primary outcome paper was
published in 2002. Michael A. Kass, MD, Professor, Department of Ophthalmology & Visual Sciences, is
the Principal Investigator/Study Chairman, and Mae O. Gordon, PhD, Professor, Division of Biostatistics
and Department of Ophthalmology & Visual Sciences, is the Director of the Vision Research Coordinating
Center.
OHTS was the first trial to demonstrate definitively that treatment of elevated intraocular pressure (IOP)
delays or prevents the onset of glaucomatous damage. OHTS also identified risk factors for developing
primary open-angle glaucoma (POAG) including older age, higher IOP and larger cup/disc ratio, and was
the first study to identify central corneal thickness (CCT) as an independent risk factor for the development
of POAG.
To date, 51 peer-reviewed journal articles have been authored by OHTS. A full list of articles and abstracts
is available in the OHTS Bibliography.
In 2007 Becker Library performed a citation review of OHTS publications (26 articles as of August 2007).
Several articles demonstrated significant citation rates. As follows are examples of publication metrics that
were used in 2007 as well as updated examples for 2014.
As of August 2007, several of the OHTS papers were among the highly cited papers in the field of Clinical
Medicine and were core papers for the subject of Glaucoma per Thomson Reuters Essential Science
Indicators.
As of August 2007, per Thomson Reuters Essential Science Indicators, the Kass and Gordon articles
ranked in the top 0.10% of papers in Clinical Medicine based on citations (339 and 267 citations
respectively), with the Brandt article in the top 1.0% of papers (118 citations).
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Kass MA, et al. 2002. The Ocular Hypertension Treatment Study: A randomized trial determines that
topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
PMID: 12049574. 339 citations in Thomson Reuters Web of Science as of August 2007.
Gordon MO, et al. 2002. The Ocular Hypertension Treatment Study: Baseline factors that predict the
onset of primary open-angle glaucoma. PMID: 12049575. 267 citations in Thomson Reuters Web of
Science as of August 2007.
Brandt JD, et al. 2001. Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS).
PMID: 11581049. 118 citations in Thomson Reuters Web of Science as of August 2007.
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